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药用蛋白的PEG修饰方法- NH2-PEG-OH/NHS/MAL
发布时间:2019-10-15   点击次数:432次

1.修饰反应器设计—PEG-pellet 反应器

 

创新技术(反应器技术和产物移走技术)

产品:

Acrylates-peg-Acrylates

Lipoicacid-peg-Acrylates

Tosylate-peg-Acrylates

Aminooxy-PEG-Acrylates

NPC-PEG-Acrylates

SAS-PEG-Acrylates

SC-PEG-Acrylates

SCM-PEG-Acrylates

SG-PEG-Acrylates

SS-PEG-Acrylates

SVA-PEG-Acrylates

 

2.固相吸附法制备PEG修饰蛋白

产品包括:

NH2-PEG-SH

NH2-PEG-Biotin

NH2-PEG-OPSS

NH2-PEG-OH

NH2-PEG-Hydrazide

NH2-PEG-Silane

NH2-peg-Acrylates

NH2-peg-Lipoicacid

NH2-peg-Acetylthio

NH2-PEG-NitrophenylCarbonates (NPC)

NH2-PEG-ValericAcids

NH2-PEG-Acrylamide

NH2-PEG-Bromide(Br)

NH2-PEG-Vinylsulfone(VS)

NH2-PEG-Methacrylate(MA)

NH2-PEG-Iodoacetate(IA)

NH2-PEG-Chloride

DBCO-PEG-NH2

TCO-PEG-NH2

Tetrazine-PEG-NH2

NH2-PEG-Folate

NH2-PEG-CHEMS

 

固相吸附法与液相吸附法的比较

产品包括:

Epoxides-PEG-COOH

ValericAcids-PEG-COOH

Acrylamide-PEG-COOH

Bromide-PEG-COOH

VS-PEG-COOH

Methacrylate-PEG-COOH

IA-PEG-COOH

Chloride-PEG-COOH

DBCO-PEG-COOH

TCO-PEG-COOH

Tetrazine-PEG-COOH

Folate-PEG-COOH

CHEMS-PEG-COOH

 

3.PEG醛制备单修饰的药用蛋白

产品包括:

OPSS-PEG-CHO

Hydrazide-PEG-CHO

Silane-peg-CHO

Acrylates-peg-CHO

Lipoicacid-peg-CHO

Tosylate-peg-CHO

Acetylthio-peg-CHO

NPC-PEG-CHO

SAS-PEG-CHO

SC-PEG-CHO

SCM-PEG-CHO

SG-PEG-CHO

SS-PEG-CHO

SVA-PEG-CHO

Epoxides-PEG-CHO

Valeric Acids-PEG-CHO

Acrylamide-PEG-CHO

Bromide-PEG-CHO

VS-PEG-CHO

Methacrylate-PEG-CHO

IA-PEG-CHO

Chloride-PEG-CHO

DBCO-PEG-CHO

TCO-PEG-CHO

Tetrazine-PEG-CHO

Folate-PEG-CHO

CHEMS-PEG-CHO

 

粒细胞集落刺激因子 (G-CSF)

产品列表:

Hydrazide-PEG-OPSS

Silane-peg-OPSS

Acrylates-peg-OPSS

Lipoicacid-peg-OPSS

Tosylate-peg-OPSS

Acetylthio-peg-OPSS

Aminooxy-PEG-OPSS

NPC-PEG-OPSS

SAS-PEG-OPSS

SC-PEG-OPSS

SCM-PEG-OPSS

SG-PEG-OPSS

SS-PEG-OPSS

SVA-PEG-OPSS

Epoxides-PEG-OPSS

ValericAcids-PEG-OPSS

Acrylamide-PEG-OPSS

Bromide-PEG-OPSS

VS-PEG-OPSS

Methacrylate-PEG-OPSS

IA-PEG-OPSS

Chloride-PEG-OPSS

DBCO-PEG-OPSS

TCO-PEG-OPSS

Tetrazine-PEG-OPSS

Folate-PEG-OPSS

CHEMS-PEG-OPSS

 

三批PEG30-rhG-CSF产品的制备

产品:

COOH-PEG-OH

MAL-PEG-OH

NHS-PEG-OH

N3-PEG-OH

Alkyne-PEG-OH

HS-PEG-OH

Biotin-PEG-OH

CHO-PEG-OH

OPSS-PEG-OH

Hydrazide-PEG-OH

Silane-peg-OH

Acrylates-peg-OH

Lipoicacid-peg-OH

Tosylate-peg-OH

Acetylthio-peg-OH

Aminooxy-PEG-OH

NPC-PEG-OH

SAS-PEG-OH

SC-PEG-OH

SCM-PEG-OH

SG-PEG-OH

SS-PEG-OH

SVA-PEG-OH

Epoxides-PEG-OH

ValericAcids-PEG-OH

Acrylamide-PEG-OH

Bromide-PEG-OH

VS-PEG-OH

Methacrylate-PEG-OH

IA-PEG-OH

Chloride-PEG-OH

DBCO-PEG-OH

TCO-PEG-OH

Tetrazine-PEG-OH

Folate-PEG-OH

CHEMS-PEG-OH

 

修饰和剂型化产品质量达到高水平

产品:

Silane-peg-Hydrazide

Acrylates-peg-Hydrazide

Lipoicacid-peg-Hydrazide

Tosylate-peg-Hydrazide

Acetylthio-peg-Hydrazide

Aminooxy-PEG-Hydrazide

NPC-PEG-Hydrazide

SAS-PEG-Hydrazide

SC-PEG-Hydrazide

SCM-PEG-Hydrazide

SG-PEG-Hydrazide

SS-PEG-Hydrazide

SVA-PEG-Hydrazide

Epoxides-PEG-Hydrazide

ValericAcids-PEG-Hydrazide

Acrylamide-PEG-Hydrazide

Bromide-PEG-Hydrazide

VS-PEG-Hydrazide

Methacrylate-PEG-Hydrazide

IA-PEG-Hydrazide

Chloride-PEG-Hydrazide

DBCO-PEG-Hydrazide

TCO-PEG-Hydrazide

Tetrazine-PEG-Hydrazide

Folate-PEG-Hydrazide

CHEMS-PEG-Hydrazide

 

引入巯基的方法制备PEG修饰蛋白

产品列表:

Tosylate-peg-Lipoicacid

Acetylthio-peg-Lipoic acid

Aminooxy-PEG-Lipoicacid

NPC-PEG-Lipoic acid

SAS-PEG Lipoic acid

SC-PEG-Lipoic acid

SCM-PEG-Lipoic acid

SG-PEG-Lipoic acid

SS-PEG-Lipoicacid

SVA-PEG-Lipoicacid

Epoxides-PEG-Lipoicacid

ValericAcids-PEG-Lipoic acid

Acrylamide-PEG-Lipoicacid

Bromide-PEG-Lipoicacid

VS-PEG-Lipoicacid

Methacrylate-PEG-Lipoicacid

IA-PEG-Lipoicacid

Chloride-PEG-Lipoicacid

DBCO-PEG-Lipoicacid

TCO-PEG-Lipoicacid

Tetrazine-PEG-Lipoicacid

Folate-PEG-Lipoic acid

CHEMS-PEG-Lipoic acid

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